British Air Force Typhoon jets have conducted a mission with French aircraft in a combined operation on an subterranean weapons facility in Syria operated by the IS group, according to the British defence ministry.
The site, pinpointed through surveillance, was thought to be storing arms and explosives, the statement said, and was positioned in mountainous terrain just to the north of the historic site of Palmyra in the heart of Syria.
"Our fighter planes used Paveway IV guided bombs to target a number of access tunnels down to the facility... initial indications indicate the strike was effective," officials stated.
There was no sign of any civilian casualties in the attack on Saturday evening and all the aircraft made a safe return, the MoD added.
The Typhoon fighters were backed up by a Voyager refuelling tanker.
Daesh - also known as Daesh - enforced extremist governance over significant areas in Syria and Iraq before its territorial defeat in 2019.
"This operation demonstrates our UK leadership, and resolve to stand shoulder to shoulder with our partners, to eliminate any re-emergence of IS and their violent and radical beliefs in the region," UK Defence Secretary John Healey said.
British military aircraft have carried out surveillance missions over Syria to "deter any attempted resurgence" of IS subsequent to its military defeat at the battle of Baghuz in 2019, the ministry said.
"I must thank all the members of our armed forces who took part in this strike for their skill and their courage," the Defence Secretary said. "They were part of numerous UK service members stationed over the holidays. This mission, to take out militants who endanger our way of life, highlights how British military are always on standby, all year round, ensuring Britain's security within its borders and strong abroad."
During December, the American forces executed what it described as a "major assault" on Daesh sites in the country, subsequent to an attack killed two American soldiers and a civilian interpreter in the Palmyra area.
The U.N. reports IS still has between 5,000 and 7,000 fighters in Iraq and Syria.